Study on the volume of gastric mucosal blood flow and change of acid secretion in rats with gastric ulcer

34 male sprague—dawley rats were randomly separated into 3 groups. An experimental model of gastric ulcer by means of causing regurgitation of all duodenal content and that of healing gastric ulcer by diversion were established by operation. Gastric juice pH,the volume of gastric mucosal blood flow(GMBF), the density of G cell in antrum mucosa and the number of parietal cell were determined and histomorphological inspection was made. compared with the control group it was shown that a chronic ulcer of 8.84±3.08 (cm~2)~(-3) was developed in antrum on the lesser curvature of stomach, in the gastric ulcer group gastric juice pH was increased, the volume of GMBF decreased by an average of 22％, the density of G cell and the number of parietal cell increased respectively by 23％ and 38％. In the healed gastric ulcer group,gastric juice pH was lower, the average increase of GMBF was 25％,the decrease in the density of G cell and the number of parietal cell were respectively 18％ and 26％ as compared with that of the gastric ulcer group. Mucosal anaemia and high peracidity may be important factors of causing ulcer. An increased mucosal blood supply and decreased gastric acid secretion may promote the healing of ulcer.