An Clinical analysis of drug-induced liver disease

Objective:To enhance the understanding of drug hepatitis by analyzing the etiology and clinical feature of 175 cases with drug-induced liver disease.Methods:Clinical data of 175 patients with drug-induced hepatitis diagnosed from 2003 to 2008 were reviewed. Medication history,clinical manifestations,liver function tests,serum markers and response of cessation of drug medication,and so on were studied with a view to find the causes and clinical features.Result:The etiological drugs were herbal medicine (26.3%),antituberculosis drugs (23.4%),anti-infectious drugs(10.9%),digestant(8.0%),drugs of dermatology(6.3%),cardiovascular drugs(4.6%),antithyroid drug(3.4%),anti-exclusion drugs(3.4%),antineoplastic agent(2.9%),anti-psychotic drugs (2.3%),anti-hyperosteogeny drugs(2.3%),weight-reducing aid(1.7%),diabetes's drugs(1.1%),and so on.Conclusion:The factors to influence drug hepatitis include the kinds of drugs to be used,duration of drugs used,combined use of drugs,age and gender.