The clinical significance of serum non-high density lipoprotein cholesterol level in patient with nonalcoholic fatty liver

Objective To study the clinical significance of serum non-high density lipoprotein cholesterol(non- HDL-C)level in patient with nonalcoholic fatty liver.Methods The levels of total protein(TP),albumin(Alb),glob- ulin(Glo),aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),direct bilirubin (DBIL),immediate biliruhin(IBIL),glucose(Glu),total cholesterol(TC),triglycerides(TG),high density lipopro- tein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A-Ⅰ(apoA-Ⅰ)and aimlipopro- tein B(apo B)were determined in 973 suhjects taken physical examination and the ratio of apo B/aim A-Ⅰ,LDL-C/ HDL-C,apo B/HDL-C and TC/HDL-C were calculated.These serum biochemical marks were analytically compared with those of 89 patients with nonalcoholic fatty liver and 202 healthy subjects.Results The detection rate of fatty liver was 9.15%.The rate of male patients(12.50%)was higher than that of female patients(5.99% ,P0.05).There were significant differences between the levels of ALT,IBIL,TG,HDL-C,LDL-C,aim A-Ⅰ,non-HDL-C,aim B/apo A-Ⅰ,LDL-C/HDL-C,apo B/HDL-C and TC/HDL-C in 59 male patients and control group(P0.05,P0.01),also the levels of AST,TBIL,DBIL,IBIL,Gin,TC,TG,LDL-C,apo A-Ⅰ,non-HDL-C,apo B/apo A-Ⅰ,LDL-C/ HDL-C,apo B/HDL-C and TC/HDL-C in 30 female patients and control group(P0.05,P0.01).The non-HDL-C was obviously correlated with TC,LDL-C,TG,HDL-C,apo A-Ⅰ,apo B,apo B/apo A-Ⅰand TC/HDL-C(r= 0.4113～0.9893,P0.01).Conclusions The metabolism disorders exist in patients with nonalcoholic fatty liver. Early determination of serum non-HDL-C level may be helpful to know the metabolism condition of plasma lipids.