The association between metabolic syndrome and the risk factors for diabetic nephropathy in type 2 diabetic patients

Objective:To investigate the association between metabolic syndrome and the risk factors for diabetic nephropathy in type 2 diabetic patients. Methods:607 type 2 diabetic patients were divided into 4 groups,based on whether complicated with diabetic nephropathy and/or metabolic syndrome,and their clinic data were analyzed.The risk factors for diabetic nephropathy were filtrated with logistic regression. Results: Systolic blood pressure,diastolic blood pressure,body mass index(BMI),waist circumference,fasting plasma uric acid,TG,insulin,HOMA index were higher in thos in DM+MS group than those in DM-MS group.Age,duration of diabetes,glycosylated HbA1c,HDL-c were lower in those in DN+MS than those in DN-MS group.With logistic regression analysis the followings were independent diabetic nephropathy risk factors: metabolic syndrome,duration of diabetes,smoking,systolic blood pressure,BMI,glycosylated HbA1c,TG,LDL-c and HOMA index. Conclusion: Metabolic syndrome is one of the independent diabetic nephropathy risk factors.Most of the component of the metabolic syndrome are joined in the development of diabetic nephropathy,and they interacted each other.