The correlation between adhesion molecule in peripheral blood monocytes and oxidized low density lipoprotein in patients with coronary heart disease

Objectives To investigate the changes and significances of the levels of adhesion molecules in peripheral blood monocytes(PBMs) and oxidized low density lipoprotein(ox-LDL) in patients with coronary heart diseases(CHD).Methods The expressions of lymphocyte function-associated antigen-1(LFA-1,or CD11a/CD18) and intercellular adhesion molecule-1(ICAM-1 or CD54) were measured by direct immunofluorescence technique with flow cytometry.The level of ox-LDL was detected by ELISA.Results Expressions of LFA-1 and ICAM-1 and level of ox-LDL in peripheral monocytes were significantly higher in CHD group than those in control subjects(P 0.05).The level of ox-LDL was the highest in patients with acute coronary syndrome(P 0.05).Correlations between the expressions of LFA-1 and ICAM-1 in monocytes and the level of ox-LDL were significant(P 0.05).Conclusions The expressions of LFA-1 and ICAM-1 and the level of ox-LDL were increased in peripheral monocytes,which were significantly correlated with the severity of CHD,and may be used for forecasting the severity of coronary artery lesion.