Clinical Significance of N-terminal Pro-Brain Natriuretic Peptide、C-Reactive Protein and Homocysteine in Patients with Acute Myocardial Infarction

Objective To investigate the acute myocardial infarction( AMI) patients plasma N-terminal probrain natriuretic peptide( NT-proBNP),C reactive protein( CRP) and homocysteine( Hcy) level and its clinical significance.Method Immune chemiluminescence was used to determine the plasma NT-proBNP in 100healthy persons and 90 patients with AMI,using latex-enhanced turbidimetric method determination of CRP,by enzymatic cycling assay for detection of Hcy and AMI of patients in the hospital and the subsequent followup,to observe the prognosis.Results AMI patients plasma NT-proBNP concentration( 534.55 ± 106.44 ng /L),significantly higher than that in control group( 158.13 ± 18.93 ng / L),the difference was statistically significant( P 0.01).The level of CRP was significantly higher than the control group.The difference was statistically significant( P 0.01).While the Hcy level was significantly higher than that of the control group.The difference was statistically significant( P 0.01).Follow-up of 90 patients with AMI results,cardiovascular events of plasma NT-proBNP,CRP,Hcy was significantly higher than that in non cardiovascular eventgroup,there was significant difference between the two groups( P 0.05).Conclusion NT-proBNP concentration greatly increases after the AMI,and Hcy as well as CRP are significantly higher in the experimental group than those in the normal control group.NT-proBNP,CRP and Hcy are all involved in thc pathogenesis of acute myocardial infarction process,and can predict patients long-term forecast cardiac function recovery.