Effect of recombinant human erythropoietin on deep second degree scald wound healing of rats skin

Objective To observe the effect of recombinant human erythropoietin on deep second degree scald wound healing of rats skin. Methods A model of deep second degree scald wound in rats was used, All healthy SD rats were randomly divided into four groups: low-doze group (50 U / ml rHuEPO), mid-doze group (100 U / ml rHuEPO), high-doze group(200 U / ml rHuEPO)and NS control group, the process of deep second degree scald wound healing were observed on the level of micropathology with HE staining, and microvessal density (MVD) were detected with immunohistochemistry staining technique after 3 days, 5 days, 7 days, 14 days and 21 days of scald. Results Compared with NS control group, the ratio of wound healing rats in erythropoietin groups were higher and the wound healing time was shorter and MVD was higher. Conclusion It is suggested Erythropoietin could accelerate tissue microvascular formation and deep second degree scald wound healing.