Research of Helicobacter pylori infection in gastric cancers and precancerous lesions

Aim To study the role of Helicobacter pylori (Hp) infection in precancerous conditions and gastric cancers.Methods A total of 548 patients was diagnosed with chronic superficial gastritis(CSG,n=163),chronic atrophic gastritis(CAG,n=207),intestinal metaplasia(IM,n=71),dysplasia(DYS,n=45) and gastric carcinomas(GC,n=62).by endoscopy and histopatholgy.Hp was examined by Warthin-Starry method.Results The detection rates of Hp in CAG(42.5%),IM(76.1%),DYS (88.9%) and GC(72.5%) were significantly higher than that in CSG (23.9%,P0.05 or P0.01).The prevalence rates varied by age,with an upward trend of IM,DYS and GC(P0.05),but a downward trend of CSG (P0.05).The Hp infectious rates of intestinal type(68.4%) was higher than that of diffuse type(41.7%) in gastric carcinomas (P=0.05).The trend of biopsy site from the lesser and greater curvature of antrum,and a gulus and the lesser and greater curvature of gastric body,the prevalence of Hp positively of CAG,IM and DYS were upward,Hp positive rates in IM and DYS were obviously higher than that in CSG in the lesser and greater curvature of gastric body(P0.05).Conclusion Hp may be a risk factor in the development of CSG to CAG to IM to DYS to cancerous lesion.The intestinal type gastric carcinomas is close associated with Hp infection.Biopsies should take multiple sites in the stomach for histopathology and Hp examination.