Research in Mechanism of Sepsis-induced Cardiac Dysfunction

Myocardial dysfunction is a common complication in patients with sepsis.The detailed pathophysiology of sepsis-induced myocardial dysfunction still remains unclear.In recent years,study shows that mitochondrial dysfunction and circulating myocardial depressant factor(TNF-α,IL-6,ET-1)regulation plays an important role.In addition,the underlying mechanisms of myocardial dysfunction include nitric oxide,reactive oxygen species damage,role of Toll-like receptors,cell apoptosis and etc..Here is to review the pathophysiology of sepsis-induced myocardial dysfunction.