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2011•Chinese Journal of New Drugs and Clinical RemediesRequires access

Determination of rat plasma protein binding rate of 2-methoxyestradiol

Bin Du

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Abstract

AIM To develop a HPLC method for the determination of the plasma protein binding rate of 2-methoxyestradiol(2-ME)in rat.METHODS The equilibrium dialysis was carried out to determine the protein binding rate of 2-ME in rat plasma.RESULTS The plasma protein binding rates of 2-ME at high,middle and low concentrations(2,4,8 mg·L-1)were(85.2 ± 3.4)%,(82.1 ± 5.3)%,(83.0 ± 5.2)%,respectively.CONCLUSION The method is sensitive,accurate,simple and reproducible,and meets the requirement of biological sample analysis.The plasma protein binding rate of 2-ME shows no concentration dependence,which provides better security for clinical medication.

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AIM To develop a HPLC method for the determination of the plasma protein binding rate of 2-methoxyestradiol(2-ME)in rat.METHODS The equilibrium dialysis was carried out to determine the protein binding rate of 2-ME in rat plasma.RESULTS The plasma protein binding rates of 2-ME at high,middle and low concentrations(2,4,8 mg·L-1)were(85.2 ± 3.4)%,(82.1 ± 5.3)%,(83.0 ± 5.2)%,respectively.CONCLUSION The method is sensitive,accurate,simple and reproducible,and meets the requirement of biological sample analysis.The plasma protein binding rate of 2-ME shows no concentration dependence,which provides better security for clinical medication.

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Available abstract

AIM To develop a HPLC method for the determination of the plasma protein binding rate of 2-methoxyestradiol(2-ME)in rat.METHODS The equilibrium dialysis was carried out to determine the protein binding rate of 2-ME in rat plasma.RESULTS The plasma protein binding rates of 2-ME at high,middle and low concentrations(2,4,8 mg·L-1)were(85.2 ± 3.4)%,(82.1 ± 5.3)%,(83.0 ± 5.2)%,respectively.CONCLUSION The method is sensitive,accurate,simple and reproducible,and meets the requirement of biological sample analysis.The plasma protein binding rate of 2-ME shows no concentration dependence,which provides better security for clinical medication.

Key concepts: Chemistry, Plasma protein binding, Plasma concentration, Blood proteins, Human plasma, Chromatography, Plasma, 2-Methoxyestradiol

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