Cervical mucinous adenocarcinoma:a pathologic analysis of twenty-one cases

Purpose To improve the early correct diagnosis and avoid misdiagnosis of cervical mucinous adenocarcinoma.Methods Twenty-one cases of cervical mucinous adenocarcinoma were reviewed and analyzed retrospectively.The expression of CEA and Ki-67 was detected in the tumor by immunohistochemical staining(LABC method).Results Of the twenty-one cases,three cases(14.3%) were missed out,in which one was missed out by TCT and the others by biopsy;four cases(19.0%) were diagnosed by biopsy as adenocarcinoma in situ with invasion not be excluded,and then further confirmed as invasive adenocarcinoma by LEEP;one case(4.8%) was diagnosed as cervicitis at first and was further detected as adenocarcinoma by LEEP;twelve cases(57.1%) were directly diagnosed as adenocarcinoma by biopsy;one case(4.8%) was diagnosed as adenocarcinoma with unknown origin,and then as cervical adenocarcinoma after hysterectomy.Immunohistochemically,ten cases were CEA positive(47.6%) and the expression of Ki-67 was increased(20%).Conclusions Understanding of the cytologic and histologic features of adenocarcinoma in cervix might improve its early detection and correct diagnosis,so that timely treatment is guaranteed for patients.