Efficacy of 0.1% tacrolimus ointment combined with asiaticoside cream ointment for treatment of facial corticosteroid dependent dermatitis

Objective To investigate the efficacy of 0.1% tacrolimus ointment combined with asiaticoside cream ointment for treatment of facial corticosteroid dependent dermatitis. Methods 60 cases with facial corticosteroid dependent dermatitis were included in the study, of which the observation group of30 patients was treated with 0.1% tacrolimus ointment cream for 4 weeks, then treated with asiaticoside for 20 weeks, while the control group of 30 patients was treated with 0.1% tacrolimus monotherapy for 4weeks.The clinical efficacy and safety for two groups were compared. Results Scaling,papules,pustules,pigmentation and other symptom scores in the observation group had significantly improved(P0.05)than the control group. The total effective rate of the observation group was 86.7%, significantly higher than the control group(P 0.05). Side effects for two groups were comparable. Conclusion 0.1%tacrolimus ointment combined asiaticoside in treatment of facial cream ointment corticosteroid dependent dermatitis has a very significant effect,which can significantly improve the clinical symptoms,improve patient outcomes and it is worthy of clinical application.