Clinical Efficacy of Facial Seborreheic Dermatitis with 0.03% Topical Tacrolimus Ointment

Objective To investigate the clinical efficacy and safety of topical 0.03% tacrolimus ointment for the treatment of patients with facial seborreheic dermatitis.Methods Seventy-eigth patients were treated with topical 0.03% tacrolimus ointment or bufexamac cream twice a day in a randomized trial.and the clinical symptom and sign scores were recorded before and after treatment.Meanwhile the adverse events were observed.Results The effective rates of the two groups were 87.50% and 60.53% respectively.Tacrolimus(0.03%) ointment was significantly more effective than that of the bufexamac cream in the patients with seborreheic dermatitis.7 cases(17.50%) were reported to have local burning and itching after the first weeks treatment.the rates of adverse events were higher in tacrolimus groups than that in bufexamac groups,but there were no statistis differences(P0.05).Conclusions Tacrolimus ointment 0.03% may be a safe and effective treatment option for the patients with facial seborreheic dermatitis.