Expressions of MMP-2/CXCR4 and their clinical significance in renal clear cell carcinoma tissues

Objective To investigate expressions of matrix metalloproteinase-2(MMP-2) and CXC chemokine receptor 4(CXCR4) in renal clear cell carcinoma(RCCC) tissues and their relationship with clinicopathological characteristics. Methods Expressions of MMP-2 and CXCR4 in 79 specimens of renal clear cell carcinoma tissues and 43 specimens of normal renal tissues were detected by immunohistochemical PV-6000 technique. Results The positive rates of MMP-2 and CXCR4 in renal clear cell carcinoma tissues were significantly different from those in normal renal tissues(χ2=36.520,45.009,P0.01). Furthermore,expressions of MMP-2 and CXCR4 in renal clear cell carcinoma tissues had a significant relationship with clinical stages of tumor and lymph node metastasis(χ2=3.978-5.657,P0.05) while not with gender and age of patients and differentiation of cancer (χ2=0.000-2.321,P0.05). Positive expression of MMP-2 was positively related to that of CXCR4 in renal clear cell carcinoma (r=0.561,P0.01). Conclusions Expressions of MMP-2 and CXCR4 in renal clear cell carcinoma tissues are significantly related to the genesis,development,metastasis and clinicopathologic parameters of tumors,and may play an important role in the progression of renal clear cell carcinoma.