Long prognostic value of B-natriuretic peptide on admission in patients with chronic heart failure

Objective:To evaluate the long prognostic value of plasma B-natriuretic peptide(BNP) on predicting cardiovascular events after hospital discharge in patients with chronic heart failure(CHF).Method:Patients with CHF(n=134) were included in this study.Plasma BNP level was obtained by a rapid immunofluorescence assay in all patients.Left ventricular end diastolic diameter(LVEDD) and cardiothoracic ratio(CRT) were performed within 24 h before or after catheterization.All CHF patients were received conventional therapy and the rates of cardiac death and rehospitalization were used as end points during 3-year follow up.Result:①LVEDD,CRT and BNP were increased in patients with cardiac events compared with patients without cardiac events(P0.01).②Multivariant logistic analysis showed that the independent factors for cardiac events in patients with CHF was BNP(OR=1.005,95%CI 1.002-1.007).③The areas under the receiver operating curve(ROC),when BNP was used to predict cardiac death of CHF,was 0.846(95%CI 0.771-0.922).For predicting cardiac death in patients with CHF,BNP cutoff point of 720.5 ng/L had a sensitivity of 76.5%,a specificity of 75.2%.④The survival rate of patients in group of BNP≤702.5 ng/L was much higher than that in group of BNP702.5 ng/L(OR=4.383,95%CI 1.407-13.650).Kaplan-Meier cumulative survival analysis supported the above results.Conclusion:Plasma BNP is an independent predictor for prognosis of patients with CHF.