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Current Research of CXC Chemokine Ligand-10

Guan-Qi Gao

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Abstract

CXC chemokine ligand-10 belongs to the family of non-ELR-CXC chemokine,which participates in many autoimmune diseases.It can not only recruit specific subtypes of leukocytes to inflammation sites,but also reduce the blood supply to tumors and inhibit the growth of tumor.Meanwhile,CXCL10 and its receptor CXCR3 are significantly increased in liver inflammation,thyroid follicular epithelial cells and infiltration of inflammatory cells.This article reviewed the structure,biological function and the relationship of CXC chemokine ligand-10 and its receptor with multiple diseases.

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What this paper is about

CXC chemokine ligand-10 belongs to the family of non-ELR-CXC chemokine,which participates in many autoimmune diseases.It can not only recruit specific subtypes of leukocytes to inflammation sites,but also reduce the blood supply to tumors and inhibit the growth of tumor.Meanwhile,CXCL10 and its receptor CXCR3 are significantly increased in liver inflammation,thyroid follicular epithelial cells and infiltration of inflammatory cells.This article reviewed the structure,biological function and the relationship of CXC chemokine ligand-10 and its receptor with multiple diseases.

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Available abstract

CXC chemokine ligand-10 belongs to the family of non-ELR-CXC chemokine,which participates in many autoimmune diseases.It can not only recruit specific subtypes of leukocytes to inflammation sites,but also reduce the blood supply to tumors and inhibit the growth of tumor.Meanwhile,CXCL10 and its receptor CXCR3 are significantly increased in liver inflammation,thyroid follicular epithelial cells and infiltration of inflammatory cells.This article reviewed the structure,biological function and the relationship of CXC chemokine ligand-10 and its receptor with multiple diseases.

Key concepts: CXCR3, CXC chemokine receptors, CXCL9, CXCL10, CXCL13, CCL21, Chemokine receptor, Chemokine

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