CXCL16 and CXCR6 in inflammation-associated diseases

Many of clinical diseases including tumors are associated with inflammation,and chemokines and their receptors are attracted special attention.CXC chemokine ligand 16 (CXCL16) and its receptor CXC chemokine receptor 6 (CXCR6) were recently found to be expressed in various inflammatory diseases (such as glomerulonephritis,pulmonary diseases,atherosclerosis,coronary artery disease,rheumatoid arthritis,et al) and in inflammation-associated cancers (such as prostate cancer,breast cancer,colorectal cancer,etc.).Through interacting with CXCR6,CXCL16 participates in the process of recruiting inflammatory cells to local disease tissues and thus impacts the prognosis of disease,the proliferation of tumor cells and the induction of angiogenesis.Further explore the expression and effect of CXCL16 and its receptor CXCR6 would provide valuable information for clinic diagnosis of inflammatory diseases and prognosis in inflammation-associated cancers.