TRANSDERML FENTANYL FOR THE RELIEF OF PAIN AFTER OPERATION UNDER GEN-ERAL ANESTHESIA

Objective: To evaluate the safety and efficacy of transdermal fentanyl to relieve pain after operation under general anesthesia. Method: 60 patients undergoing elective abdominal surgery under general anesthesia were randomly entered into two groups, durogesic group ( group A, 30 cases) and placebo group ( group B , 30 cases) . About 9 hours before operation, medicinal chart with fentanyl release 50μg/ h was set on the infraclavicular skin of group A and a sticking paper without medicament on the same position of group B. All patients experienced general anesthesia with midazolam, fentanyl, enflurane, and succinylcholine. After surgery, Sp02, RR, ECG and NBP were monitored continuously. VAS score, BCS score and Ramsay score were measured. The incidence of nausea, vomiting, pruritus, and urinary retention were measured. Result: (1)The analgesic effect was satisfactory in group A, and was significantly more effective than that in group B (P 0. 01 ) ; (2) The evidence of respiratory depression was not found in any patients; (3) There was no difference between two groups in the incidence of adverse effects such as nausea, vomiting, pruritus and urinary retention. Conclusions; Transdermal fentanyl (50μg/h) is safe and efficient in relieving pain after operation under general anesthesia. The postoperative analgesia did not obviouly increase the incidence of aversove side effects.