Detection of serum human epididymis protein 4 and its significance in diagnosis of ovarian cancer

Objective To detect the level of serum human epididymis protein 4(HE4) in the patients with ovarian cancer and approach the significance of serum HE4 in the diagnosis of ovarian cancer.Methods ELISA mothod was used to detect the levels of serum HE4 in ovarian cancer group,benign ovarian tumor group,other malignant gynecology tumor group and malignant tumor of other organs group.The changes of the serum HE4 level in ovarian cancer group before and after operation were detected.The effects of the serum HE4 level and CA215 level in ovarian cancer group in the diagnois of ovarian cancer were compared.Results The serum HE4 levels ovarian cancer group was (242.76±113.40)pmol·L-1 and the positive rate was 70.59%,they were higher than those in benign ovarian tumor group(85.57 pmol·L-1±63.40 pmol·L-1,7.02%),other malignant gynecology tumor group (73.16 pmol·L-1±12.27 pmol·L-1,0.00%),malignant tumor of other organs group(80.65 pmol·L-1±16.24 pmol·L-1,0.00%)and control group(43.95 pmol·L-1±18.16 pmol·L-1,0.00%)(P0.01);the serum HE4 level in ovarian cancer group after operation(134.83 pmol·L-1±56.20 pmol·L-1) was lower than before operation(242.76 pmol·L-1±113.40 pmol·L-1)(P0.05).The positive rate of serum HE4 in the early ovarian cancer was higher than that of seum CA125.The sensitiveity of HE4 combined with CA125 was higher than each of them,the specificity of HE4 combined with CA125 was lower than each of them(P0.05).Conclusion The HE4 serum has important significance in the diagnosis of ovarian cancer,especially,its sensitivity and specificity are all better than CA125 in the diagnosis of early ovarian cancer,the detection of HE4 combined with CA125 can elevate the early diagnosis rate of ovarian cancer.