Application of human epididymis protein 4 in diagnosis of ovarian carcinoma

Objective To discuss the diagnostic value of human epididymis protein 4(HE4) level to ovarian carcinoma of gynecology.Methods The HE4 level was detected with ELISA technique in 62 cases of pelvic ovarian cancer(ovarian carcinoma group),38 cases of benign ovarian tumors(benign ovarian tumor group),and 100 cases of healthy women(control group),which was compared with the result of CA125 kit.Results The serum HE4 level was significantly higher in ovarian carcinoma group((443.33±244.59)pmol/L) than that in ovarian benign tumor group((113.18±79.95)pmol/L) and control group((72.52±42.45)pmol/L)(P0.01).HE4 had higher sensitivity and specificity than CA125,and also had good agreement with CA125(Kappa=0.708).With 91.94% of sensitivity and 92.03% of specificity,the joint detection of HE4 and CA125 was more superior to the single detection of HE4 or CA125.Conclusion Being one of new markers of the diagnosis of ovarian cancer,HE4 level has a high diagnostic value to ovarian carcinoma.