Expression and significance of SPARC and VEGF in breast invasive ductal carcinoma tissues

OBJECTIVE: To explore the expressions and role of SPARC and VEGF in invasive ductal carcinoma of the breast.METHODS: The expressions of SPARC and VEGF in 65 pathologically diagnosed invasive ductal carcinoma of breast and 20 cases of benign breast tissues were detected by immunohistochemical technique.RESULTS: Compared with breast benign lesions group,SPARC protein was expressed in both tumor cells and stromal cells of the breast carcinoma,but the positive expression rate of SPARC were higher in the stromal cells and lower in the tumor cells.The positive expression rate of SPARC in carcinoma cells of breast invasive ductal carcinoma with lymph node metastasis was significantly higher than that without lymph node metastasis(P0.05).The positive expression rate of SPARC in carcinoma cells in invasive ductal carcinoma of breast in TNM staging Ⅰ,Ⅱ was significantly lower than that in Ⅲ(P0.05).The positive expression rate of VEGF in carcinoma cells in invasive ductal carcinomas of breast with lymph node metastasis was significantly higher than that without lymph node metastasis(P0.05).VEGF in stromal cells of the breast carcinoma had associations with the age,the expression of estrogen receptor and the progesterone receptor.There was a positive correlation between SPARC and VEGF in invasive ductal carcinoma(P0.05).CONCLUSION: SPARC and VEGF are involved in the tumorgenesis and progression of the invasive ductal carcinoma,and may play synergetic roles in invasion and metastasis of the disease.