Clinical significance of PML-RARα fusion gene detection in patients with acute promyelocytic leukemia

Objective To investigate the significance of detection of PML-RARα fusion gene in patients with acute promyelocytic leukemia(APL) before and after treatment and to study the relationship between PML-RAR fusion gene levels in patients and acute promyelocytic leukemia(APL) lesion process. Methods PML-RARα fusion gene levels of APL in bone marrow before and after treatment were detected by RT-PCR. Results There were 41 positive cases of detection of PML-RARα fusion gene among 51 patients with APL. The positive rate was 80.4%. 51 patients with acute promyelocytic leukemia(APL) were treated for 18 months(followed up), 3 in death and 3 positive. The positive rate was 5.9%. Conclusion Detection of PML-RARα fusion gene is important for APL diagnosis. Molecular relapse can be detected early by PML- RARα fusion gene regular detection. And acute promyelocytic leukemia(APL) can be treated in time to avoid hematological relapse.