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2000•Acta HaematologicaRequires access

PML/RARα(+) Hypergranular Acute Promyelocytic Leukemia (M3) Developing into an M3 Acute Myelocytic Leukemia without PML/RARα

Guillermo J. Ruíz‐Argüelles, Guillermo J. Ruiz‐Delgado, Virginia Reyes‐Núñez

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Abstract

The case of an adult with PML/RARalpha(+) hypergranular acute promyelocytic leukemia (M3) that evolved into a rapidly fatal M3 acute myelocytic leukemia without PML/RARalpha after a complete and molecular remission had been achieved, is presented. Only 7 such cases have been published in the literature. The possible origin of this either leukemic relapse or secondary malignancy is briefly discussed, focusing on the fact that this diagnosis could only be defined by adequate molecular biology studies in the leukemic cells.

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What this paper is about

The case of an adult with PML/RARalpha(+) hypergranular acute promyelocytic leukemia (M3) that evolved into a rapidly fatal M3 acute myelocytic leukemia without PML/RARalpha after a complete and molecular remission had been achieved, is presented. Only 7 such cases have been published in the literature. The possible origin of this either leukemic relapse or secondary malignancy is briefly discussed, focusing on the fact that this diagnosis could only be defined by adequate molecular biology studies in the leukemic cells.

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OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The case of an adult with PML/RARalpha(+) hypergranular acute promyelocytic leukemia (M3) that evolved into a rapidly fatal M3 acute myelocytic leukemia without PML/RARalpha after a complete and molecular remission had been achieved, is presented. Only 7 such cases have been published in the literature. The possible origin of this either leukemic relapse or secondary malignancy is briefly discussed, focusing on the fact that this diagnosis could only be defined by adequate molecular biology studies in the leukemic cells.

Key concepts: Acute promyelocytic leukemia, Myelocytic leukemia, Leukemia, Promyelocytic leukemia protein, Malignancy, Medicine, Acute leukemia, Cancer research

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PML/RARα(+) Hypergranular Acute Promyelocytic Leukemia (M3) Developing into an M3 Acute Myelocytic Leukemia without PML/RARα — Research Paper | ScholarLens