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2010•Journal of Beijing University of AgricultureRequires access

Liver Morphology and Serological Changes in Spleen-Deficiency Rat with Sijunzi Decoction

XU Jian-qin

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Abstract

Healthy SD rats were randomly divided into control group,spleen deficiency group and Chinese herb treatment group(Sijunzi decoction treatment).Reseen-deficiency model in rats were treated with Sijunzi decoction.Histology observation revealed that compared with control group,hepatocytes of spleen deficiency group became small,nuclear-cytoplasmic ratio decreased;there were more intercellular fat bubbles.The normal appearance of hepatic cord disappeared.Sijunzi decoction recovered hepatocytes and reduced the number of fat bubbles.The results showed that serum ALT,DBIL,TBA of the spleen deficiency rats increased significantly(P0.05),AST,ALP and TG decreased significantly(P0.05),Sijunzi decoction had well accommodation effect.Sijunzi decoction could recover damages of hepatocytes,and adjust hepatic function indexes in spleen-deficiency rats.

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What this paper is about

Healthy SD rats were randomly divided into control group,spleen deficiency group and Chinese herb treatment group(Sijunzi decoction treatment).Reseen-deficiency model in rats were treated with Sijunzi decoction.Histology observation revealed that compared with control group,hepatocytes of spleen deficiency group became small,nuclear-cytoplasmic ratio decreased;there were more intercellular fat bubbles.The normal appearance of hepatic cord disappeared.Sijunzi decoction recovered hepatocytes and reduced the number of fat bubbles.The results showed that serum ALT,DBIL,TBA of the spleen deficiency rats increased significantly(P0.05),AST,ALP and TG decreased significantly(P0.05),Sijunzi decoction had well accommodation effect.Sijunzi decoction could recover damages of hepatocytes,and adjust hepatic function indexes in spleen-deficiency rats.

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Available abstract

Healthy SD rats were randomly divided into control group,spleen deficiency group and Chinese herb treatment group(Sijunzi decoction treatment).Reseen-deficiency model in rats were treated with Sijunzi decoction.Histology observation revealed that compared with control group,hepatocytes of spleen deficiency group became small,nuclear-cytoplasmic ratio decreased;there were more intercellular fat bubbles.The normal appearance of hepatic cord disappeared.Sijunzi decoction recovered hepatocytes and reduced the number of fat bubbles.The results showed that serum ALT,DBIL,TBA of the spleen deficiency rats increased significantly(P0.05),AST,ALP and TG decreased significantly(P0.05),Sijunzi decoction had well accommodation effect.Sijunzi decoction could recover damages of hepatocytes,and adjust hepatic function indexes in spleen-deficiency rats.

Key concepts: Decoction, Spleen, Internal medicine, Endocrinology, Histology, Medicine, Chemistry

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