The Dynamic Changes and Clinical Meaning of BNP in Serum of Patients with Early Acute Myocardial Infarction

Objective To discuss the dynamic changes and also the clinical significance of BNP in the patients with no cardiac insufficiency after the onset of AMI. Methods Serum BNP of 20 SA cases, 20 UA cases, 20 healthy cases was tested and the serum BNP of 40 AMI cases also be testde in 2h, 4h, 6h, 24h after the onset time. Determine the serum cTnI concentration of AMI patients after 6h of onset. Results BNP level of UA group(145.07±78.15)pg/mL are obviously higher than SA group(32.05±7.75 pg/mL), P0.01. BNP level in 4h, 6h, 24h after AMI onset(220.15±126.30) pg/mL、(335.83±170.41)pg/mL、(489.90±244.73)pg/mL) are obviously higher than UA group(145.07±78.15)pg/mL, P0.01, and with the onset time prolonging, BNP level in AMI group is increasing obviously. the BNP level and cTnI are having positive relativity in 6h after the AMI onset, r=0.874,P0.01. Conclusion The serum BNP level may be another biochemistry marker to predict the prognosis of AMI patient.