Research Progress on the Correlation between Cell Signaling Pathway and Liver Fibrosis

Hepatic fibrosis is regarded as a pathologically repair reaction of the liver caused by various kinds of chronic liver diseases. It is characterized by an excessive proliferation and abnormal deposition of extracellular matrix. Hepatic fibrosis is a middle pathological stage in the procession from various chronic liver diseases to hepatic cirrhosis. Recently,researches on cell signal passageway and hepatic fibrosis have made great progress. Here is to make a review of the correlation of signal pathways of protein kinase activated by mitogen,NF-κB,TGF-β / Smad Wnt,and relationship of hepatic fibrosis,so as to understand the molecular mechanism of hepatic fibrosis further and roundly.