Comparison study of behavioral and histological changes between pilocarpine-induced epilepsy model and pentylenetetrazole kindling model in rats.

Objective To investigate and compare the behavioral changes,neuron loss of hippocampus and mossy fiber sprouting between pilocarpine-induced status epilepticus(SE) model and pentylenetetrazole(PTZ) kindling model in rats.Methods After two different epilepsy models were made,Vedio was adopted to observe the behavioral changes.Nissl staining and Neo-timms' staining were separately used to observe and compare the neuron loss of hippocampus and mossy fiber spouting in the dentate gyrus(DG) at different time points during epileptogenisis.ResultsTwo different epilepsy models have their characteristic behavioral changes.No neuron loss and mossy fiber sprouting were found in PTZ kindling model,whereas obvious neuron loss and mossy fiber sprouting were found in pilocarpine model.Conclusion PTZ kindling model resembles absence epilepsy in human,and pilocarpine-induced status epilepticus model resembles chronic temporal epilepsy and is a ideal temporal epilepsy model.