2005•Study Journal of Traditional Chinese MedicineRequires access

Study on the Modulating Mechanism of Colonic TNF-αand IL-10 mRNA Expression in CD rats with Acupuncture and Moxibustion

Qian Jing-lan

Abstract

Objective: To observe the effect of acupuncture and moxibustion on the colonic expressions of TNF-αand IL-10mRNA in crohn's disease(CD)rats. Methods :The rats which were set up into CD's model were randomly divided into four groups including normal control group(NC),model control group(MC),herbs-partition moxibustion group(HPM)and electroapuncture group(EA).Tianshu(ST25,bilateral)and Qihai(RN6)were used in HPM and EA separately.The expressions of TNF-αand IL-10mRNA in colonic mucosa of CD rats were observed by situ hybridization. Results :The expressions of TNF-αand IL-10mRNA were markedly increased in CD rats compared with normal rats, and decreased significantly after herbs-partition moxibustion or electropuncture treatment. Conclusion :Acupuncture- moxibustion therapy can relieve or eliminate the intestinal inflammation maybe through effectively restraining the colonic expression of TNF-αmRNA, regulating the balance between IL-10mRNA and TNF-αmRNA in CD rats.

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Key concepts: Moxibustion, Medicine, Acupuncture, Tumor necrosis factor alpha, Rat model, In situ hybridization, Normal group, Messenger RNA