Granular cell tumor of the breast:a clinicalpathologic analysis of 9 cases

Purpose To investigate the clinicalpathological characteristics,diagnosis,differential diagnosis and prognosis of granular cell tumor of the breast.Methods 9 cases of granular cell tumor of the breast were studied by histopathological observation and immunohistochemical staining.Results The study included 8 cases of benign granular cell tumor(BGCT) and 1 atypical granular cell tumor(AGCT).The tumor was characterized by clear cell boundary,aboundant cytoplasm,full of acidophilic granules and it also infiltrated beyond the edge of the main tumor.Immunohistochemical study demonstrated that tumor cells were reacted with CD68,S-100,vimentin,but negative with EMA and SMA.Those benign ones do not metastasize and such patients have favorable prognosis.Conclusions Granular cell tumor of the breast is a rare tumor that can be misdiagnosed by frozen section,clinical and cytological tests.The disease should be enforced to study and avoid being operated excessively and unnecessarily.