Preliminary study of quantitative evaluating left ventricular systolic function by automated motion tracking of mitral annular displacement(MAD) in patients with left ventricular noncompaction

Objective This study sought to evaluate the clinic value of left ventricular systolic function by automated motion tracking of mitral annular displacement(MAD) in patients with left ventricular noncompaction(LVNC).Methods Forty-three patients with LVNC and thirty-nine healthy subjects were enrolled in this study.Left ventricular end-diastolic dimension(LVDd) was measured with two-dimensional echocardiography,left ventricular end-systolic volume(ESV),left ventricular end-diastolic volume(EDV) and left ventricular ejection fraction(LVEF) were measured by biplane Simpson's method with two-dimensional echocardiography.The maximal displacement of the four points of mitral annulus,the displacement of midpoints and percentages(MADmid,MADmid%)of mitral annulus were measured with tissue motion tracking of mitral annular displacement(TMAD).Compared these targets with healthy subjects,and analyzed the correlation between LVEF and the TMAD parameter.Results(1)Compared with healthy subjects,LVEF decreased significantly in patients with LVNC(P0.01),the EDV,ESV and LVDd increased significantly in patients with LVNC(P0.01).(2)Compared with healthy subjects,the four points of MAD,MADmid and MADmid% decreased significantly in patients with LVNC(P0.01).(3)There was significant correlation between LVEF and the four points of MAD,MADmid and-MADmid% in patients with LVNC(P0.01).And the ratio of midpoints of MAD correlated best with LVEF among all the date of MAD(r=0.753,0.794).Conclusions There is good correlation between TMAD and biplane Simpson's method with two-dimensional echocardiography for measuring left ventricular systolic function.TMAD is a new technology to evaluate left ventricular systolic function with LVNC exactly and objectively.