Comparative of effects of clozapine,risperidone and ziprasidone on body weight and blood glucose

Objective To investigate the effects of clozapine,risperidone and ziprasidone on body weight and blood glucose of patients with schizophrenia.Methods A total of 190 patients who met the criteria of CCMD-3 for schizophrenia were assigned to clozapine group,risperidone group and ziprasidone group.Using single drug for 6 months.Body weight and fasting plasma glucose were measured before and 1、2、3、6 months after drug administration.Results After 2 months treatment,body weight in clozapine group and risperidone group were highter than before(P0.05).After 3 months treatment,blood glucose in clozapine group and risperidone group were highter than berore(P0.05).But in ziprasidone group,we didn't find the differences between before and after treatment(P0.05).Conclusions Clozapine and Risperidone can effect body weight and blood glucose of patients with schizophrenia.Ziprasidone has no effects on body weight and blood glucose.