Azone,A New Penetration Enhancer

Azone is a highly effective and low poisonous penetration enhancer in percutaneous absorption of drugs.The most suitable concentration of azone can be determined by experiments on drugs and their forms.Usually,the quantity used is about 2-10%.If the concentration is too high,it is possible to produce theopposite effects.The mechanism of azone is obscure,but experiments have proved that it can promotemost hydrophilic drugs passing through the stratum corneum and reduce their detaining time.The synthesisand application of azone will promote the rapid development of its externally used preparation and TTS.