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2013•Zhongguo yaofangRequires access

Content Determination of Triamcinolone Acetonide in Triamcinolone Urea Cream by UV-visible Spectrophotometry

Cheng Shu-fen

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Abstract

OBJECTIVE:To establish a method for the content determination of triamcinolone acetonide in Triamcinolone urea cream. METHODS:UV-visible spectrophotometry was adopted. Using triphenyltetrazolium chloride and tetramethylammonium hydroxide as reaction solution,ethanol as solvent,triamcinolone acetonide was determined at 485 nm. RESULTS:The linear range of triamcinolone acetonide was 4.992-22.464 μ g/ml(r=0.999 9) with an average recovery of 100.21%(RSD=0.63%,n=9).CONCLUSIONS:The method is simple,sensitive and accurate,and it is suitable for quality control of the preparation.

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OBJECTIVE:To establish a method for the content determination of triamcinolone acetonide in Triamcinolone urea cream. METHODS:UV-visible spectrophotometry was adopted. Using triphenyltetrazolium chloride and tetramethylammonium hydroxide as reaction solution,ethanol as solvent,triamcinolone acetonide was determined at 485 nm. RESULTS:The linear range of triamcinolone acetonide was 4.992-22.464 μ g/ml(r=0.999 9) with an average recovery of 100.21%(RSD=0.63%,n=9).CONCLUSIONS:The method is simple,sensitive and accurate,and it is suitable for quality control of the preparation.

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Available abstract

OBJECTIVE:To establish a method for the content determination of triamcinolone acetonide in Triamcinolone urea cream. METHODS:UV-visible spectrophotometry was adopted. Using triphenyltetrazolium chloride and tetramethylammonium hydroxide as reaction solution,ethanol as solvent,triamcinolone acetonide was determined at 485 nm. RESULTS:The linear range of triamcinolone acetonide was 4.992-22.464 μ g/ml(r=0.999 9) with an average recovery of 100.21%(RSD=0.63%,n=9).CONCLUSIONS:The method is simple,sensitive and accurate,and it is suitable for quality control of the preparation.

Key concepts: Triamcinolone acetonide, Chemistry, Spectrophotometry, Chromatography, Urea, Solvent, Acetonide, Medicine

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Content Determination of Triamcinolone Acetonide in Triamcinolone Urea Cream by UV-visible Spectrophotometry — Research Paper | ScholarLens