Clinicopathological Features of Hepatitis B-associated Glomerulonephritis in Hunan

ObjectiveTo study the clinicopathological features of 38 cases with hepatitis B-associated glomerulonephritis (HBG).MethodsHistopathological picture, ultrastructure and immunohistochemical reaction of the renal tissues obtained from kidney puncture were observed by light microscopy, electron microscopy and immunohistochemical staining in 38 cases with HBG. According to their ages, patients were divided into Group 1 (children group) and Group 2 (youth and adult group). Their clinical data and pathologic features were analyzed.ResultsIn Group 1, all cases had history of edema and revealed positive HBsAg, HBeAg and cAb (100%). Patients complicated with nephropathy syndrome accounted for 79.2%, and 91.6% of them were boys. As for Group 2, majority of the patients had history of edema (71.4%), 64.2% of them were positive carriers of HBsAg, HBcAg and cAb. Their complication of nephropathy syndrome amounted to 42.8%, males were predominately involved (71.4%).ConclusionsClinicopathological features of HBG are characterized by nephropathy syndrome and serologically positive marker of HBV, mostly seen in children. Pathologically, it belongs mainly to membranous nephropathy. Immunohistochemical markers of HBsAg and HBcAg are important criteria for diagnosis of HBG.