The Relationship between Angiotensin II Type I Receptor Gene Polymorphism and Essential Hypertension

Aim:To investigate the angiotensin ⅡtypeⅠ receptor gene A1166C polymorphism in essential hypertensive Chinese Han Methods:Blood pressure, body mass index, fasting blood glucose and serum cholesterol and triglyceride were measured in 120 hypertensives, and 86 normotensives. DNA was extracted from peripheral blood leukocytes. Polymerase Chain Reaction (PCR) combined with restriction enzyme digestion was used to detect the variation of A1166 allele. Results:The systolic blood pressure (SBP) and diastolic blood pressure (DBP)of hypertensive group were significantly higher than those of control; while other clinic features such as fasting blood glucose, body mass index and serum lipid level showed no difference between them; The AC genotype frequency and C1166 allele frequency of AT1R gene in EH patients were higher than that of control (AC genotype: 0.181 vs 0.058, P 0.01; C allele: 0.091 vs 0.029, P 0.05); No CC homozygote genotype had been found in our study. Conclusion:The AC genotype is associated with essential hypertension and C allele may be a susceptible gene to hypertension in Chinese Han population.