The effect of immunochemotherapy on the immunocyte in advanced esophageal cancer

] Objective To investigate the change of immunocyte cell in patients with peripheral blood after chemotheropy in patients with advanced esophageal cancer.Methods Forty-eight advanced esophageal cancer patients were investigated from June 2006 to December 2007 in Anhui Provincial Hospital and Anhui Tumor Hospital,who were divided into chemotherapy group,chemotherapy + permanent immunity therapy group and chemotherapy + short term immunity therapy of large dose group.CD3+CD8+T cell、CD3+CD4+T cell、CD4+CD25+Treg cell 、and NK cell,in peripheral blood of esophageal cancer patients fore-aft therapy,were determined by flow cytometer.The change of immunocyte fore-aft therapy was analyzed by paired t-test.The change of immunocyte in different group was analyzed by one-factor analysis of variance.Results There was no difference between the proportion of CD3+CD8+T cell、CD3+CD4+T cell and NK cell before and after chemotherapy(P0.05) in chemotherapy group,chemotherapy + permanent immunity therapy group and chemotherapy + short term immunity therapy of large dose group,while the mean proportion of CD4+CD25++ regulatory T(CD4+CD25high regulatory T)cell all decreased,which showed statistical difference(P0.05).The proportion of CD4+CD25+Treg cell increased in chemotherapy group(P=0.035) and chemotherapy + permanent immunity therapy group(P=0.039).The change of the proportion of CD4+CD25+Treg cell increased and CD4+CD25high Treg decreased did not show statistical significant in three groups,which was P=0.86,P=0.14.Conclusion Immunochemotherapy do not have an advantage over chemotherapy alone in the aspect of improving immune function in advanced esophageal cancer patients.