Esomeprazole for Duodenal Ulcer with Helicobacter Pylori

Objective: To compare esomeprazole with lansoprazole,omeprazole triple therapy on duodenal ulcer with Helicobacter pylori.Methods: 84 duodenal ulcer patients with Helicobacter pylori were randomly divided into three groups.Esomeprazole group(28 cases): esomeprazole 20mg + amoxicillin 1g + furazolidone 100mg,2 times a day for 7 days,then taking esomeprazole 20mg,once daily for 21 days;lansoprazole group(28 cases): lansoprazole 15mg + amoxicillin 1g + furazolidone 100mg,2 times a day for 7 days,then tak-ing lansoprazole 15mg,once daily for 21 days;Ogilvy pull azole group(28 cases): Omeprazole 20mg + amoxicillin 1g + furazolidone 100mg,2 times a day for 7 days,then taking omeprazole 20mg,once daily for 21 days.repeated endoscopy and detect Hp,observed rates of abdominal pain relief,ulcer healing rate,Hp cure rates and adverse drug reactions after the end for 4 weeks.Results: Esomeprazole group,lansoprazole group and omeprazole group's ulcer healing rate was 100%,85.7%,82.1%,HP cure rate was 85.7%,60.7%,64.3%,The Hp eradication rate and ulcer healing rate of esomeprazole group is higher than the lansoprazole group and omeprazole group,the difference was statistically significant(P 0.05).The Hp eradication rate and ulcer healing rate of Lansoprazole group and omeprazole group was no significant difference(P 0.05).The adverse reactions of three groups were little,with better security.Conclusion: The triple therapy with esomeprazole is superior to the triple therapy of lansoprazole and omeprazole on duodenal ulcer with Helicobacter py-lori and is worthy of wider application.