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2013•Zhejiang Journal of Integrated Traditional Chinese and Western MedicineRequires access

Effect of Emodin on Renal Interstitial Fibrosis in Rats

Yu Zhong

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Abstract

Objective: To study the effect of emodin on renal interstitial fibrosis in rats.Methods:Rat model of renal interstitial fibrosis was prepared by unilateral ureteral obstruction and was intervened by low,medium,and high dosages of emodin(25,50,and 80 mg/kg body weight),respectively.The survival condition of the rats was ob served and on day 28 after intervention,rats from all groups were sacrificed for detection of serum C-I,PIIIP,HA and TGF-βmRNA in kidney tissues.Results: Compared to the model group,rats in emodin groups had bet ter survival rate,reduced serum C-I,PIIIP,and HA(P0.05) and decreased expression of TGF-βmRNA in renal tissues(P0.05).Conclusion: Emodin can play a role of anti-fibrosis in rats by decreasing the expression of TGF-βmRNA in renal tissues.

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Objective: To study the effect of emodin on renal interstitial fibrosis in rats.Methods:Rat model of renal interstitial fibrosis was prepared by unilateral ureteral obstruction and was intervened by low,medium,and high dosages of emodin(25,50,and 80 mg/kg body weight),respectively.The survival condition of the rats was ob served and on day 28 after intervention,rats from all groups were sacrificed for detection of serum C-I,PIIIP,HA and TGF-βmRNA in kidney tissues.Results: Compared to the model group,rats in emodin groups had bet ter survival rate,reduced serum C-I,PIIIP,and HA(P0.05) and decreased expression of TGF-βmRNA in renal tissues(P0.05).Conclusion: Emodin can play a role of anti-fibrosis in rats by decreasing the expression of TGF-βmRNA in renal tissues.

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Available abstract

Objective: To study the effect of emodin on renal interstitial fibrosis in rats.Methods:Rat model of renal interstitial fibrosis was prepared by unilateral ureteral obstruction and was intervened by low,medium,and high dosages of emodin(25,50,and 80 mg/kg body weight),respectively.The survival condition of the rats was ob served and on day 28 after intervention,rats from all groups were sacrificed for detection of serum C-I,PIIIP,HA and TGF-βmRNA in kidney tissues.Results: Compared to the model group,rats in emodin groups had bet ter survival rate,reduced serum C-I,PIIIP,and HA(P0.05) and decreased expression of TGF-βmRNA in renal tissues(P0.05).Conclusion: Emodin can play a role of anti-fibrosis in rats by decreasing the expression of TGF-βmRNA in renal tissues.

Key concepts: Emodin, Medicine, Kidney, Fibrosis, Rat model, Internal medicine, Urology, Dose

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