2007•Zhonghua neifenmi daixie zazhiRequires access

Association between Graves'disease and polymorphism of CTLA-4 gene in patients of the Han nationality in Tianjin area

Qiu Ming-ca

Abstract

The polymorphism of (AT) repeat within the 3' untranslated region in exon 3 of CTLA-4 gene was evaluated by PCR-SSCP in 139 patients with Graves' disease (GD) and 110 normal subjects in Tianjin. The gene frequency of 106 bp in patients with GD was significantly increased than that in the control group (RR =1.992,P0.01) while the gene frequency of 106 bp in patients with positive family history was much higher than that in patients without positive family history (RR=2.480,P0.05).The data suggest that an allele of 106 bp within 3' untranslated region in exon 3 of CTLA-4 appears to be associated with genetic susceptibility to Graves' disease in Tianjin Hen nationality

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Key concepts: Exon, Allele, Graves' disease, Single-strand conformation polymorphism, Polymorphism (computer science), Internal medicine, Gene, Untranslated region