PATHOLOGICAL OBSERVATION OF THE POISONING EFFECTS OF PARAQUAT AT THE DIFFERENT DOSES ON THE KIDNEY OF RATS

ObjectiveTo observe pathologically the poisoning effect of paraquat(PQ)at different doses on kidney of rats. MethodsSD rats were exposured to PQ at different doses intraperitoneally,and pathological changes of kidney were observed at different time points. Results①First day after PQ treatment,renal pathological changes could be seen in all groups,proximal tubule at cortical most serevely involved.No significant differences could be found at different time point for each PQ dose group.②In group 15 mg/kg and group 20 mg/kg, tubular epithelial cells of cortical showed swelling,part of which became vacuole degeneration.③ In group 35mg/kg,the karyopyknosis of the tubular epithelial cells of cortical increased.The structure of epithelium disappeared,that of glomcrulus disorganized and medulla were involved.In group 25 mg/kg and 30 mg/kg,severity of pathological changes were between that of group 20 mg/kg and group 35 mg/kg. Conclusion①The main pathological changes of kidney induced by PQ were epithelial swelling,vacuole degeneration and necrosis.② There was a positive correlation between pathological changes of kidney and the dose of PQ.③ With the poisoning dose increasing,each part of kidney were involved.