Expression of osteopontin in breast cancer and its correlation with clinicopathology and p53

Objective To investigate the expression of osteopontin(OPN) in breast cancer and its correlation with clinicopathologic characteristics and p53.Methods Immunohistochemical MaxVision assay was used to detect the expression of OPN in 125 patients with breast carcinoma and 20 cases of normal breast tissues.The relationship of OPN expression with clinicopathologic characteristics and p53 protein was analyzed.Results The positive expression rate of OPN in breast cancer was 62.4%,which was almost zero in the normal breast tissues.The expression of OPN was closely related to tumor size,axillary lymph nodes metastases and clinical phase(P0.05).OPN expression in breast cancer was positively correlated to p53(r=0.297,P0.05).Conclusion OPN is highly expressed in breast cancer,which is closely related to tumor clinical stage and pathological grade.The expression of OPN may be taken as a biological marker for estimating the occurrence and progression of breast cancer.Combined detection of OPN and p53 is helpful in evaluating patient's condition and predicting the prognosis of the patients with breast cancer.