ScholarLens Back to search
2005•Di-Si Junyi Daxue xuebaoRequires access

Changes and effect of nitric oxide during early hepatic I/R injury in rats

Du Xi

Open publisher page 0 citations

Abstract

AIM: To investigate the changes of nitric oxide and its effect during hepatic I/R injury. METHODS: One hundred and fifteen male SD rats were divided into four groups: GroupⅠ: sham operation; Group Ⅱ: 70 min ischemia followed by reperfusion with saline given intravenously; GroupⅢ: L-arg; GroupⅣ: L-NNA plus L-arg. Rats were sacrificed at 0, 1, 3, 6 and 12 h after reperfusion. Serum NO, ALT, MDA and plasma TNF-α were detected. RESULTS: Serum NO in Group Ⅱ was higher than that in GroupⅠ just after reperfusion but it then decreased significantly. Serum ALT and MDA elevated in GroupⅡ. There were significant differences at 1-6 h after reperfusion (P0.05). Plasma TNF-α increased significantly after 3 h (P0.05). L-arg, the NO donor, significantly reversed these changes (P0.05). CONCLUSION: Serum NO decreases 1 h after hepatic ischemia-reperfusion. It may play an important role in the hepatic I/R injury.

About this research paper

What this paper is about

AIM: To investigate the changes of nitric oxide and its effect during hepatic I/R injury. METHODS: One hundred and fifteen male SD rats were divided into four groups: GroupⅠ: sham operation; Group Ⅱ: 70 min ischemia followed by reperfusion with saline given intravenously; GroupⅢ: L-arg; GroupⅣ: L-NNA plus L-arg. Rats were sacrificed at 0, 1, 3, 6 and 12 h after reperfusion. Serum NO, ALT, MDA and plasma TNF-α were detected. RESULTS: Serum NO in Group Ⅱ was higher than that in GroupⅠ just after reperfusion but it then decreased significantly. Serum ALT and MDA elevated in GroupⅡ. There were significant differences at 1-6 h after reperfusion (P0.05). Plasma TNF-α increased significantly after 3 h (P0.05). L-arg, the NO donor, significantly reversed these changes (P0.05). CONCLUSION: Serum NO decreases 1 h after hepatic ischemia-reperfusion. It may play an important role in the hepatic I/R injury.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM: To investigate the changes of nitric oxide and its effect during hepatic I/R injury. METHODS: One hundred and fifteen male SD rats were divided into four groups: GroupⅠ: sham operation; Group Ⅱ: 70 min ischemia followed by reperfusion with saline given intravenously; GroupⅢ: L-arg; GroupⅣ: L-NNA plus L-arg. Rats were sacrificed at 0, 1, 3, 6 and 12 h after reperfusion. Serum NO, ALT, MDA and plasma TNF-α were detected. RESULTS: Serum NO in Group Ⅱ was higher than that in GroupⅠ just after reperfusion but it then decreased significantly. Serum ALT and MDA elevated in GroupⅡ. There were significant differences at 1-6 h after reperfusion (P0.05). Plasma TNF-α increased significantly after 3 h (P0.05). L-arg, the NO donor, significantly reversed these changes (P0.05). CONCLUSION: Serum NO decreases 1 h after hepatic ischemia-reperfusion. It may play an important role in the hepatic I/R injury.

Key concepts: Nitric oxide, Reperfusion injury, Saline, Internal medicine, Medicine, Ischemia, Endocrinology, Anesthesia

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Changes and effect of nitric oxide during early hepatic I/R injury in rats — Research Paper | ScholarLens