ScholarLens Back to search
2010•Chinese Journal of Laboratory DiagnosisRequires access

A population-based study of PPARγ2 gene polymorphism for type 2 diabetes

DU Dan-hua

Open publisher page 0 citations

Abstract

Objective To investigate the genetic association between the PPARγ gene polymorphism and type 2 diabetes.Methods 250 patients with type 2 diabetes were recruited into this study,and 337 healthy people were as controls.SNP rs1875796,a C to T base change located in intron 4 of the gene,was used as a genetic marker.PCR-based restriction fragment length polymorphism analysis was applied to genotype rs1875796(Hha I site).Results The genotype frequencies(CC:CT:TT) of rs1875796 in type 2 diabetes patients and control group were 2.8%:27.2%:70.0% and 2.7%:25.5%:71.8%.Frequencies of C allele and T allele were 16.4%:83.6% and 15.4%:84.6%.The frequencies of allele and genotype distribution showed no significance between type 2 diabetes patients and controls.Conclusion The present study suggests that the PPARγ gene rs1875796 polymorphism is unlikely to contribute to the etiology of type 2 diabetes in Chinese Han.

About this research paper

What this paper is about

Objective To investigate the genetic association between the PPARγ gene polymorphism and type 2 diabetes.Methods 250 patients with type 2 diabetes were recruited into this study,and 337 healthy people were as controls.SNP rs1875796,a C to T base change located in intron 4 of the gene,was used as a genetic marker.PCR-based restriction fragment length polymorphism analysis was applied to genotype rs1875796(Hha I site).Results The genotype frequencies(CC:CT:TT) of rs1875796 in type 2 diabetes patients and control group were 2.8%:27.2%:70.0% and 2.7%:25.5%:71.8%.Frequencies of C allele and T allele were 16.4%:83.6% and 15.4%:84.6%.The frequencies of allele and genotype distribution showed no significance between type 2 diabetes patients and controls.Conclusion The present study suggests that the PPARγ gene rs1875796 polymorphism is unlikely to contribute to the etiology of type 2 diabetes in Chinese Han.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the genetic association between the PPARγ gene polymorphism and type 2 diabetes.Methods 250 patients with type 2 diabetes were recruited into this study,and 337 healthy people were as controls.SNP rs1875796,a C to T base change located in intron 4 of the gene,was used as a genetic marker.PCR-based restriction fragment length polymorphism analysis was applied to genotype rs1875796(Hha I site).Results The genotype frequencies(CC:CT:TT) of rs1875796 in type 2 diabetes patients and control group were 2.8%:27.2%:70.0% and 2.7%:25.5%:71.8%.Frequencies of C allele and T allele were 16.4%:83.6% and 15.4%:84.6%.The frequencies of allele and genotype distribution showed no significance between type 2 diabetes patients and controls.Conclusion The present study suggests that the PPARγ gene rs1875796 polymorphism is unlikely to contribute to the etiology of type 2 diabetes in Chinese Han.

Key concepts: Genotype, Allele, Type 2 diabetes, Polymorphism (computer science), SNP, Allele frequency, Restriction fragment length polymorphism, Genetics

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
A population-based study of PPARγ2 gene polymorphism for type 2 diabetes — Research Paper | ScholarLens