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[Sperm DNA damage and unexplained recurrent spontaneous abortion].

Chengjun Liu, Aiming Wang, Wei Shang, Min Li, Weizhou Wang, Yu-liang Shen, Yong Dong Zhao

Open publisher page 3 citations

Abstract

OBJECTIVE: To explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA). METHODS: Sperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group). RESULTS: The DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05). CONCLUSION: There is a relationship between sperm DNA damage and URSA.

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What this paper is about

OBJECTIVE: To explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA). METHODS: Sperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group). RESULTS: The DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05). CONCLUSION: There is a relationship between sperm DNA damage and URSA.

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Available abstract

OBJECTIVE: To explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA). METHODS: Sperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group). RESULTS: The DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05). CONCLUSION: There is a relationship between sperm DNA damage and URSA.

Key concepts: DNA fragmentation, Sperm, Andrology, Abortion, DNA damage, Chromatin, Gynecology, Biology

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