Expression and significance of follicle-stimulating hormone receptor in prostate cancer

OBJECTIVE: To explore the significance of follicle-stimulating hormone receptor in prostate cancer throngh the research of the expression of FSHR in normal human prostate,benign prostatic hyperplasia and prostate cancer.METHODS: FSHR expressions were observed in 12 cases of normal specimens,14 cases of BPH and 45 cases of PCa tissues by immunohistochemical staining.RESULTS: There were 2 positive in normal prostate,4 positive in benign prostatic hyperplasia and 38 positive in prostate cancer.There was no significant difference between normal prostate and benign prostatic hyperplasia.But there was a significant difference between benign prostatic hyperplasia and prostate cancer.The postive rate of FSHR corresponded with the increase of tumor's pathological grading and its clinical staging,and furthermore with deeper color in cytoplasm.CONCLUSIONS: The expression of FSHR is higher in prostate cancer than that in normal human prostate and in benign prostatic hyperplasia,and the expression in prostate cancer presents a positive correlation with tumor's,sgrading and staging.The expression presents a close relation with the carcinogenesis,progression and metastasis of prostate cancer.