Value of ~(18)F-FDG PET/CT Imaging in Detection of Postoperative Recurrent or Metastasis of Ovarian Cancer

[Purpose] To evaluate the value of integrated positron emission tomography(PET)and computed tomography(CT)for depiction of recurrence ovarian carcinoma after surgery.[Methods] The model of PET/CT scanner we used is Siemens Biograph Sensation 16.Forty-three women who had previously undergone surgery for ovarian cancer were included.The patients received 18F-FDG intravenously after fasting for 4 to 6 hours.3D whole body PET/CT scans were acquired 60 min after injection.PET/CT imaging results were compared with the results of serum CA125 levels and ultrasound,CT or MRI conventional imaging.PET/CT results were compared to histologic examination after surgery and clinical follow-up to determine the diagnostic accuracy of PET/CT in the evaluation of disease status.[Results] The overall sensitivity,specificity,accuracy of PET/CT were 92.3%,100%,93.0% respectively.There was a positive correlation between serum CA125 and positive result of FDG PET/CT.PET/CT could detect recurrent lesions in 31 of 33 patients in whom increased serum CA125 level.Among the 10 patients with serum CA125 in normal range,PET/CT correctly detected recurrent foci in 5 patients.[Conclusion] PET/CT depicts recurrent ovarian carcinoma with a high sensitivity and accuracy when conventional imaging is inconclusive or negative,especially in patients with increased CA125 levels.FDG PET/CT image can help to detect occult metastasis and direct further treatment to the precise site of tumor recurrence.