ScholarLens Back to search
2003•Zhonghua putong waike zazhiRequires access

A study on the mechanism of acute portal vein thrombosis after pericardial devascularization with splenectomy for the treatment of portal hypertension

Xinguang Qiu

Open publisher page 2 citations

Abstract

Objective To study the mechanism of acute portal vein thrombosis (APVT) after pericardial devascularization with splenectomy for the treatment of portal hypertension. MethodsThe expression of intercelluar adhesion molecule-1(ICAM-1) in spleen veins of 34 patients with portal hypertension and control vessels was studied by immunohistochemistry. Samples from spleen veins were examined by HE staining. Results The ICAM-1 level was higher in the spleen vessels in portal hypertensive (PH) patients than in controls (P0.01). Eight PH cases suffered from postoperative APVT, whereas there was no APVT developed in the 34 control non PH cases undergoing splenectomy for ruptured spleen (P0.05). Conclusions The overexpression of ICAM-1 in portal system and the hyperplasia of intimal epithelium and hylinization contribute to the high incidence of APVT in PH patients undergoing pericardial devascularization.

About this research paper

What this paper is about

Objective To study the mechanism of acute portal vein thrombosis (APVT) after pericardial devascularization with splenectomy for the treatment of portal hypertension. MethodsThe expression of intercelluar adhesion molecule-1(ICAM-1) in spleen veins of 34 patients with portal hypertension and control vessels was studied by immunohistochemistry. Samples from spleen veins were examined by HE staining. Results The ICAM-1 level was higher in the spleen vessels in portal hypertensive (PH) patients than in controls (P0.01). Eight PH cases suffered from postoperative APVT, whereas there was no APVT developed in the 34 control non PH cases undergoing splenectomy for ruptured spleen (P0.05). Conclusions The overexpression of ICAM-1 in portal system and the hyperplasia of intimal epithelium and hylinization contribute to the high incidence of APVT in PH patients undergoing pericardial devascularization.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the mechanism of acute portal vein thrombosis (APVT) after pericardial devascularization with splenectomy for the treatment of portal hypertension. MethodsThe expression of intercelluar adhesion molecule-1(ICAM-1) in spleen veins of 34 patients with portal hypertension and control vessels was studied by immunohistochemistry. Samples from spleen veins were examined by HE staining. Results The ICAM-1 level was higher in the spleen vessels in portal hypertensive (PH) patients than in controls (P0.01). Eight PH cases suffered from postoperative APVT, whereas there was no APVT developed in the 34 control non PH cases undergoing splenectomy for ruptured spleen (P0.05). Conclusions The overexpression of ICAM-1 in portal system and the hyperplasia of intimal epithelium and hylinization contribute to the high incidence of APVT in PH patients undergoing pericardial devascularization.

Key concepts: Medicine, Splenectomy, Portal hypertension, Spleen, Portal vein thrombosis, Thrombosis, Adhesion, Immunohistochemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
A study on the mechanism of acute portal vein thrombosis after pericardial devascularization with splenectomy for the treatment of portal hypertension — Research Paper | ScholarLens