Analysis of the Relative Factors of Glomerular Filtration Rate and Establishing the New Formula for Measurement and Calculation

Purpose To establish an accurate,simple,safe and cheap new formula for measurement and calculation of glomerular filtration rate (GFR). Methods GFR from 122 cases of patient were determined accurately using Clearance of 99mTc-DTPA(Tc-GFR).Many clinical factors for example serum creatinine(SCr) and so on were determined simultaneously using routine method.The equation was obtained by the relationship and regression analysis for measurement and calculation GFR(MC?GFR).MC?GFR from another 83 cases of patient were measured and calculated by this equation and the creatinine clearance rate (CCr) were measured and calculated by Cockcroft/Gault formula(MC?CCr). Results The equation was tenable and the regression coefficient was signif- icantly (P0.000 1).There were positive correlation significantly among lgMC?GFR,lgMC?CCr and lgTc-GFR(P0.01-0.05).But there was no difference significantly between MC?GFR and Tc-GFR(P0.05) and there was difference significantly between MC?CCr and Tc-GFR(P0.01). Conclusions MC?GFR could replace Tc-GFR and MC?GFR was accurate,simple,safe and cheap and it should apply and popularize.