2011•Zhongguo shiyan fangjixue zazhiRequires access
Effects of Bixue Capsule on Hemorheological Changes in Rats with Acute Blood Stasis
Jia Du
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Abstract
Objective:To investigate the effects of Bixue Capsule on hemorheological changes in a rat model of acute blood stasis.Method: Sixty SD rats were divided at random into normal control group,model control group,Tongxinluo Capsule control groups,Low dose group,middle dose groups and high dose group(242,48,968 mg.kg-1 accordingly) of Bixue Capsule.Rats were treated with oral medication daily for 7 days.The acute blood stasis was induced by subcutaneous injection of large dose of adrenaline hydrochloride and ice-water socking for the rats.Then,the hemorheological parameters were observed for evaluating the effects of Bixue Capsule.Result: As compared with vehicle,Bixue Capsule obviously decreased the low shear viscosity of whole blood,the hematocrit and erythrocyte aggregation(P 0.05).Conclusion: Bixue Capsule significantly reduced the degree of red blood cells aggregation and improved blood viscosity in rats with blood stasis syndrom.