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Study on fingerprints of Yexiazhu capsules by HPLC

Rao Li-qun

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Abstract

Objective To develop a fingerprint with HPLC method for determination of the Yexiazhu capsules.Method The RP-HPLC method was used with that Hypersil ODSⅡ column was 250 mm ×4.6 mm,5 um,mobile phase was acetonitrile-0.1% phosphoric acid(gradient elution);analytic time was 65 min,the flow rate was 0.8 ml/min,and detective wavelength was at 280 nm.Results A standard HPLC fingerprint procedure of Yexiazhu capsules was developed with 17 common peaks and a similarity threshold of 0.91 established.Conclusion The method is reliable and simple which can be used for quality control of the capsule.

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What this paper is about

Objective To develop a fingerprint with HPLC method for determination of the Yexiazhu capsules.Method The RP-HPLC method was used with that Hypersil ODSⅡ column was 250 mm ×4.6 mm,5 um,mobile phase was acetonitrile-0.1% phosphoric acid(gradient elution);analytic time was 65 min,the flow rate was 0.8 ml/min,and detective wavelength was at 280 nm.Results A standard HPLC fingerprint procedure of Yexiazhu capsules was developed with 17 common peaks and a similarity threshold of 0.91 established.Conclusion The method is reliable and simple which can be used for quality control of the capsule.

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Available abstract

Objective To develop a fingerprint with HPLC method for determination of the Yexiazhu capsules.Method The RP-HPLC method was used with that Hypersil ODSⅡ column was 250 mm ×4.6 mm,5 um,mobile phase was acetonitrile-0.1% phosphoric acid(gradient elution);analytic time was 65 min,the flow rate was 0.8 ml/min,and detective wavelength was at 280 nm.Results A standard HPLC fingerprint procedure of Yexiazhu capsules was developed with 17 common peaks and a similarity threshold of 0.91 established.Conclusion The method is reliable and simple which can be used for quality control of the capsule.

Key concepts: Chromatography, Phosphoric acid, High-performance liquid chromatography, Gradient elution, Fingerprint (computing), Capsule, Chemistry, Acetonitrile

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